Familial protein S deficiency is associated with recurrent thrombosis.

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Familial protein S deficiency is associated with recurrent thrombosis.

Recent studies have demonstrated that protein C deficiency is associated with recurrent familial thrombosis. In plasma, activated protein C functions as an anticoagulant. This anticoagulant response requires a vitamin K-dependent plasma protein cofactor, referred to as protein S. Since the anticoagulant activity of activated protein C is dependent on protein S, we hypothesized that patients lac...

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Cerebral infarction and familial protein S deficiency.

References 1. Levine SR, Welch KMA: Cerebrovascular ischemia associated with lupus anticoagulant. Stroke 1987; 18:257-263 2. Levine SR, Welch KMA: The spectrum of neurological disease associated with antiphospholipid antibodies: Lupus anticoagulants and anticardiolipin antibodies. Arch Neurol 1987;44: 876-883 3. Levine SR, Welch KMA: Antiphospholipid antibodies. Ann Neurol 1989;26:386-389 4. Ya...

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Stroke and familial protein S deficiency.

To the Editor: We have read with special attention the letter of Davous et al. Because the association between hereditary protein S deficiency and cerebral arterial thrombosis is controversial,' we are reporting another case with this same association in which other members of the family were affected by arterial thrombotic diseases. A 44-year-old man was admitted to our hospital a few hours af...

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ژورنال

عنوان ژورنال: Journal of Clinical Investigation

سال: 1984

ISSN: 0021-9738

DOI: 10.1172/jci111632